From the Picrust website:

PICRUSt (pronounced pie crust) is a bioinformatics software package 
designed to predict metagenome functional content from marker gene (e.g., 16S rRNA) 
surveys and full genomes.


Because PICRUSt is a Python package, it can be setup on Odyssey using a local Anaconda clone. It is a bit more complex than a simple pip install, though.

Setup a conda clone

Follow the instructions for setting up an Anaconda clone on Odyssey, if you don't already have one.

$ module load python/2.7.11-fasrc01
$ conda create -n ody --clone $PYTHON_HOME
$ source activate ody
(ody) $ python
Python 2.7.13 |Anaconda 2.5.0 (64-bit)| (default, Dec 20 2016, 23:09:15) 
[GCC 4.4.7 20120313 (Red Hat 4.4.7-1)] on linux2
Type "help", "copyright", "credits" or "license" for more information.
Anaconda is brought to you by Continuum Analytics.
Please check out: and

Setup h5py

As noted in the instructions for setting up h5py on Odyssey, h5py can be pip installed into your conda clone, but you should choose a module for HDF5 based on your likely compiler and MPI library stack.

$ source activate ody
discarding /n/sw/fasrcsw/apps/Core/Anaconda/2.5.0-fasrc01/x/bin from PATH
prepending /n/home_rc/akitzmiller/.conda/envs/ody/bin to PATH
(ody) $ module load hdf5/1.8.12-fasrc08
(ody) $ pip install h5py
Collecting h5py
  Downloading h5py-2.7.0-cp27-cp27mu-manylinux1_x86_64.whl (4.3MB)
    100% |████████████████████████████████| 4.4MB 140kB/s 
Installing collected packages: h5py
Successfully installed h5py-2.7.0
(ody) $

Install biom-format

This can be installed with a simple pip install with your clone activated

(ody) $ pip install biom-format==2.1.5

Install PICRUSt

This must be installed from an downloaded archive. The archive need not be unpacked. PyCogent will also be installed.

(ody) $ wget
--2017-07-10 13:57:57--
Connecting to||:443... connected.
Saving to: “picrust-1.1.1.tar.gz”
2017-07-10 13:57:58 (17.0 MB/s) - “picrust-1.1.1.tar.gz” saved [10826010/10826010]

(ody) $ pip install picrust-1.1.1.tar.gz 
Processing ./picrust-1.1.1.tar.gz
Collecting cogent==1.5.3 (from PICRUSt==1.1.1)
  Downloading cogent-1.5.3.tgz (3.4MB)
    100% |████████████████████████████████| 3.4MB 182kB/s 
Building wheels for collected packages: PICRUSt, cogent
  Running bdist_wheel for PICRUSt ... done
  Running bdist_wheel for cogent ... done
Successfully built PICRUSt cogent
Installing collected packages: cogent, PICRUSt
  Found existing installation: cogent 1.9
    Uninstalling cogent-1.9:
      Successfully uninstalled cogent-1.9
Successfully installed PICRUSt-1.1.1 cogent-1.5.3

(ody) $ --help
Usage: [options] {-t/--input_tree INPUT_TREE -i/--input_trait_table INPUT_TRAIT_TABLE}

[] indicates optional input (order unimportant)
{} indicates required input (order unimportant)